West Mercia Police are appealing for witnesses following a collision on the A49, Ross Road in Hereford at around 3.50pm yesterday afternoon.
The collision involved a Honda XL 125 motorcyle and a silver Volvo S80 car.
The motorcyclist, a man in his twenties, sustained serious injuries and was airlifted to hospital.
Road closures were in place whilst emergency services were in attendance.
Investigating officers would like to speak to anyone who witnessed the collision. If you have any information, please call 101.